General Information

  • ID:  hor004227
  • Uniprot ID:  Q9GLN8
  • Protein name:  Angiotensin 1-7
  • Gene name:  AGT
  • Organism:  Pan troglodytes (Chimpanzee)
  • Family:  Serpin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pan (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0004867 serine-type endopeptidase inhibitor activity
  • GO BP:  GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0042981 regulation of apoptotic process; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  DRVYIHP
  • Length:  7(25-31)
  • Propeptide:  MAPAGVSLRATILCLVAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAIFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTG
  • Signal peptide:  MAPAGVSLRATILCLVAWAGLAAG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  AGTR2
  • Target Unid:  A0A2I3S7W4
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 15 seconds ( PubMed ID: 9740616 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9GLN8-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004227_AF2.pdbhor004227_ESM.pdb

Physical Information

Mass: 100622 Formula: C41H62N12O11
Absent amino acids: ACEFGKLMNQSTW Common amino acids: DHIPRVY
pI: 7.54 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -77.14 Boman Index: -1948
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.14
Instability Index: 54.29 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  9740616
  • Title:  NA